Chronic Obstructive Pulmonary Disease (COPD) makes it difficult for the respiratory system to deliver oxygen to the lungs. The scientist wants to use a computer simulation to model how COPD affects heart rate and respiratory rate during exercise. She will compare the simulated subject’s heart and respiratory rates over time to a normal subject.

Place the steps of the investigation in the most appropriate order, starting with the change that should be made to simulate COPD in the individual.