Fatty acid synthesis occurs in the cytosol, while fatty acid breakdown occurs in the mitochondria.
In biochemistry and metabolism, the cytoplasm and endoplasmic reticulum of the cell are where fatty acids are synthesized.
In prokaryotes and eukaryotes, the cytosol is where fatty acid molecules are broken down to produce acetyl-CoA, which enters the citric acid cycle, as well as NADH and FADH2.
The process of turning fatty acids into acetyl-CoA is known as fatty acid oxidation, and it mostly takes place in mitochondria.
Inside the mitochondrial matrix, -oxidation breaks down fatty acids.
One palmitate molecule, a fatty acid with 16 carbons, completely oxidizes to produce 129 ATP molecules.
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