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During anaphase 1 of meiosis, the homologues chromosome are pulled toward opposite poles of the cell, i.e. they are segregated.

Homologous chromosomal separation triggers the onset of anaphase I. Reformed nucleoli and the nuclear envelope are shown. The nuclear membrane starts to break down, the centrosomes start to separate, and the chromosomes coil up. Sister chromatids line up to the cell's equator, and spindle fibres begin to develop.

The term "homologous chromosome" refers to a pair of two chromosomes, typically one inherited from the mother and one from the father. The length, centromere location, and staining pattern of the homologous chromosome are identical. Chromosomes will couple up inside the cell during conception.

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